Hepatoprotective Effects of Commelina diffusa Extracts on Alcoholic Liver Injury in Mice
Hà Quang Thanh, Mai Thành Chung, Nguyễn Mai Trúc Tiên, Nguyễn Thị Thu Hương*
Trung tâm Sâm và Dược liệu thành phố Hồ Chí Minh - Viện Dược liệu
*Email: huongsam@hotmail.com
present study was envisaged to investigate the intervention effects of Commelina diffusa extracts on alcoholic liver injury in mice. Alcoholic liver injury was induced in the experimental model by ethanol administering with gradually increasing concentrations every 7 days (10, 20, 30, 40%), continuous administration for 4 weeks and pretreatment by Commelina diffusa extracts and silymarin (100 mg/kg) at 1 hour before ethanol administration. The results showed that pretreatment with 96% ethanol extracts of Commelina diffusa (0.21 and 0.42 g/kg) significantly reduced the ethanol-elevated serum level of aspartate transaminase (AST, aspartate aminotransferase), alanine transaminase (ALT, alanine aminotransferase). Besides, malondialdehyde (MDA) was found to significantly decrease while glutathione (GSH) in liver was significantly enhanced, such effects were similar to a reference drug silymarin. Both 50% ethanol extracts (0.49 and 0.98 g/kg) and aqueous extracts (0.36 and 0.72 g/kg) of Commelina diffusa did not show any effects on the above parameters.
Journal of Medicinal Materials, vol. 24, No 6/2019 (Page 362 - 368)
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