Evaluation of Anti-gout Activity in Experimental Animal Models of Celery Capsules

Evaluation of Anti-gout Activity in Experimental Animal Models of Celery Capsules

Nguyễn Thu Hằng1, Nguyễn Thùy Dương2,*, Nguyễn Văn Phương1, Hoàng Thị Quỳnh1

1Bộ môn Dược liệu - Đại học Dược Hà Nội;

2Bộ môn Dược lực - Đại học Dược Hà Nội

*Email: duongnt@hup.edu.vn

Celery capsules containing 300 mg of celery seed extract have been evaluated for uric acid lowering, anti-inflammatory and analgesic activities in vivo. The results showed that celery capsules at 600 mg/kg and 1200 mg/kg taken continuously for 5 days significantly reduced uric acid concentrations in mice. Celery capsules at 330 mg/kg and 660 mg/kg also reduced symptoms in monosodium urate crystal-induced mice. In addition, celery capsules at 330 mg/kg and 660 mg/kg increased the pain threshold in Randall-Selitto test. It is suggested that flavonoids are related to hypouricemia, anti-inflammatory and analgesic effects of celery capsules.

Journal of Medicinal Materials, vol. 24, No 6/2019 (Page 351 - 355)