Antioxidant and Cytotoxic Activities on HepG2 Cell Lines of Ethanol Extracts from some Medicinal Plants Collected in Southern Vietnam

Antioxidant and Cytotoxic Activities on HepG2 Cell Lines of Ethanol Extracts from some Medicinal Plants Collected in Southern Vietnam

Lý Hải Triều, Trương Triệu Minh, Phan Phượng Ngân,

Phạm Nguyễn Minh Trang, Lê Văn Minh, Nguyễn Thị Thu Hương*

Trung tâm Sâm và Dược liệu thành phố Hồ Chí Minh - Viện Dược liệu

*Email: huongsam@hotmail.com

The purpose of this research is to investigate phytochemical constituents, antioxidant, and cytotoxic activities of some medicinal plants (Syzygium cumini, Combretum quadrangulare, Zingiber zerumbet, and Clinacanthus nutans). Phytochemicals were analyzed by chemical reactions; antioxidant activity was evaluated using DPPH radical scavenging and capacity reducing powder assays; cytotoxic activity on HepG2 cancer cells was assessed through SRB assay. Results showed that medicinal materials contain flavonoids, tannins, triterpenoids, and saponins. All 96% ethanol extracts from these medicinal materials had antioxidant effect via DPPH radical scavenging ability and total capacity reducing, in which ethanol extract of Syzygium cumini leaves exhibited the strongest antioxidant activity among the various extracts with IC50 values of 2.05 and 12.15 μg/mL, respectively. Crude ethanol extract of Combretum quadrangulare leaves presented cytotoxic activity on HepG2 cancer cells with an IC50 value of 98.51 μg/mL.

Journal of Medicinal Materials, vol. 24, No 6/2019 (Pager 356 - 362)