Abutili Semen (Qingmazi)
Chingma Abutilon Seed
Chingma
Abutilon Seed is the dried ripe seed of Abutilon
theophrastii Medic. (Fam. Malvaceae). The fruit is collected in autumn when
ripe, dried in the sun, and the seed is trapped out, removed from foreign
matter.
Description:
Triangular
reniform, 3. 5-6 mm long, 2. 54. 5 mm wide, 1-2 mm thick. Externally
greyish-black or dark brown, bearing sparse white tomenta, a subelliptical hilum
at the dented part, pale brown, radially striated around the edges. Testa hard,
cotyledons 2, folded, oily. Odour, slight; taste, weak.
Identification:
(1) Transverse
section: Epidermal cells 1 layer, flattened-rectangular, sometimes
differentiated to unicellu-lar non-glandular hairs; hypodermal cells 1 layer,
slightly radially prolated. Palisade cells 1 row, cylindrical, up to about 88 µm
long, heavily thick-walled, linear lumina visible at the upper part, the
terminal end expended, containing small globular crystals. Pigment cells 4-5
layers, containing yellowish-brown or reddish-brown contents. Cells of
endosperm and cotyledons, containing fatty oil droplets and aleurone grains,
cells of cotyledons also containing a few of fine clusters of calcium oxalate.
:
(2) Add 2 g of the
powder to a Soxhlet’s extractor, and add appropriate quantity of petroleum
ether (60-90oC), heat under reflux to the extract colourless, cool,
discard the petroleum ether. Evaporate the residue to dryness, add 30 ml of
ethanol, ultrasonicate for 30 minutes, cool, filter, concentrate the filtrate
to 2 ml as the test solution. Prepare a solution of 2 g of Abutili Semen in the same
manner as the reference drug solution Carry out the method for thin layer
chromatography (Appendix VI B ) , using silica gel G as the coating substance
and a mixture of chloroform, acetone, methanol and formic acid (3 : 1 : 0. 5 :
0.1) as the mobile phase. Apply separately 5 µl of each of the above two
solutions to the plate. After developing and removal of the plate, dry it in
air, spray with a 10% solution of sulfuric acid in ethanol, heat at 110°C to
the spots clear. Examine under ultraviolet light at 365 nm, the fluorescent
spots in the chromatogram obtained with the test solution correspond in position
and colour to the fluorescent spots in the chromatogram obtained with the
reference drug solution.
Foreign matter:
Not more than 1
percent (Appendix IX A).
Water:
Not more than 10.0
percent (Appendix IX H, method 2).
Total ash :
Not more than 7. 0
percent (Appendix IX K).
Extractives:
Carry out the hot
extraction method for determination of ethanol-soluble extractives (Appendix X A),
using anhydrous ethanol as solvent, not less than 17. 0 percent
Property and Flavor:
Neutral; bitter.
Meridian
tropism:
Large intestine,
small intestine and bladder meridians.
Actions:
To clear heat and
remove toxin, drain dampness, relieve nebula.
Indications:
Red or white
dysentery, stranguria with slow pain, swelling abscess, sore and toxin, nebula.
Administration and dosage:
3-9 g.
Storage:
Preserve in
a cool and dry place.
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