TANNINS AS METAL ION CHELATORS
Phenolics can affect the
biological availability or activity of metal ions by chelating the metal (McDonald,
M.; Mila, I.; Scalbert, A. J. Agric. Food Chem. 1996, 44, 599). Chelation
requires appropriate patterns of substitution and a pH above the pKa of the
phenolic group. Bacterial siderophores with multiple phenolic groups and very
high affinities for essential metals such as iron have been characterized
(Harris, W.R.; Carrano, C.J.; Cooper, S.R.; Sofen, S.R.; Avdeef, A.E.; McArdle,
J.V.; Raymond, K.N. J. Am. Chem. Soc. 1979, 101, 6097). The similarity between
siderophore ortho-dihydroxy substitution pattern and the substitution patterns
on condensed and hydrolyzable tannins suggests that tannins may also have very
high affinities for metals.
Phenolic-metal ion complexes are
often colored, and it has been suggested that characteristic colors can be used
to identify specific arrangements of phenolic groups (Mole, S.; Waterman, P.G.,
Oecologia 1987, 72, 137-147). However, these methods have not been adequately
tested and are not recommended.
It is widely believed that
tannin-chelated metal ions are not bioavailable. For example, consumption of large
quantities of tea or other tannin-rich foods is sometimes associated with
deficiency diseases such as anemia (Baynes, R.D. and Bothwell, T.H. Ann Rev.
Nutr. 1990 10, 133). In many ecosystems, the slow decomposition of tannin-rich
leaves has been attributed in part to the low levels of biologically available metal
ions (Vituosek, P.M.; Turner, D.R.; Parton, W.J. and Sanford, R.L. Ecology
1994, 75, 418). The populations of microfauna essential to leaf decomposition
and soil formation are unable to grow when metals are unavailable.
Metal ion chelation can alter the
redox potential of the metal, or prevent its participation in redox reactions.
Thus metal ion chelators can be inhibitors or enhancers of Fenton-driven oxidative reactions.
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