Artabotrys suaveolens Bl.
[From Greek, artao = support and botrys
= bunch of grapes and suavis = sweet]
Common name:
Akar cenana (Malay).
Physical description:
It is a rainforest climber of Burma, Java,
Moluccas and the Philippines. The bark is blackish and smooth and the stems are
hooked. Leaves: simple, alternate and
exstipulate. The petiole is glabrous, channeled and 3mm–5mmlong. The blade is
dark green, glossy, glabrous, leathery, elliptic and 8.5 cm×3.5 cm–5 cm× 3 cm.
The apex of the blade is acuteacuminate; the base is tapering; and the margin
is entire and slightly acuminate. The flowers are 1 cm long, whitish and
tomentose.The calyx comprises of 3 sepals which are ovate, acute and 2.5mm
long. The corolla comprises of 2 distinct whorls of 3 petals which are valvate.
The petals are dilated at the base, and develop a cylindrical limb and a
recurved apex. The fruits are green, glossy, ellipsoid, 1.4 cm×5mm ripe
carpels, each containing a single seed (Fig. 6).
Fig. 6. Artabotrys suaveolens Bl.
Pharmaceutical interest:
The pharmacological properties of Artabotrys
suaveolens Bl. are unexplored. One might set the hypothesis that
isoquinoline alkaloids, such as artabotrine, suaveoline and artabotrinine,
could be responsible for both antibacterial and emmenagogue properties (Maranon
J, 1929; Barger G et al., 1939; Santos AC et al., 1932).
Artabotrine from Artabotrys zeylanicus alleviates yeast cells cultured in
vitro (Wijeratne EMK et al., 1995). Both liriodenine and
atherospermidine characterized from Artabotrys uncinatus are cytotoxic in
vitro (WuYC et al., 1989).The leaves of Artabotrys odoratissimus display
an antifertility property (Chakrabarti B et al., 1968). Norstephalagine
and atherospermidine characterized from the bark of Artabotrys maingayi relax
rat uterine KCl- and oxytocin-induced contractions induced by potassium
chloride and the rhythmic contractions induced by oxytocin (Cortes D et al.,
1990).
Antiplasmodial property: An interesting feature of the genus Artabotrys
is the production of antimalarial sesquiterpenes peroxides. One such
compound is yingzhaosu A, from Artabotrys uncinatus, a plant used in
India to make aromatic tea. Arteflene, a synthetic peroxide developed from
yingzhaosu A given (single oral dose 25 mg/Kg) in a phase 3, open-labeled
randomized clinical trial, was not effective in curing Plasmodium falciparum
malaria (Radloff PD et al., 1996).
Uses:
In Malaysia and Indonesia, an infusion of the leaves provides an aromatic
drink used to treat cholera. In the Philippines, a decoction of the bark and
roots is drunk to promote menses and to aid recovery from childbirth.
References
Barger G, et al. (1939) J Chem Soc (London),
991–997.
Chakrabarti B, et al. (1968) J Ind
Med Assoc 51(5): 227–229.
Maranon J. (1929) Philip J Sci 38:
259–265.
Radloff PD, et al. (1996) Am J Trop
Med Hyg 55(3): 259–262.
Santos AC, et al. (1932) Nat Appl
Sci Bull (Univ Philip) 2: 407–415.
Wijeratne EMK, et al. (1995) Tetrahedron
51(29): 7877–7882.
Wu YC, et al. (1989) Phytochem 28(8):
2191–2196.
Warning:
Caution must be taken as the toxic effects of this plant are unknown.
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