Discovery of 3 New Penicillin
Compounds with Clinically Relevant Antibacterial Activity According to a recent
study from Germany, researchers have isolated three new penicillin-like
compounds with clinically relevant antibacterial activity – known as penialidins
1-3 – from the fungus Penicillium growing within the leaves of a medicinal
plant from Cameroon. The plant, Garcinia
lucida Vesque (syn. Garcinia nobilis
Engl.) is related to the well known garcinias in commerce, mangosteen and Garcinia cambogia, common in weight loss
products. Garcinia lucida Vesque bark
is used in Camaroonian food and medicine.
“The bark is used as an additive
to palm wine production and in distilling fermented palm wine to produce
liquor. The bark and the seeds, dried or fresh, are widely used for medicinal
purposes to prevent food poisoning and to cure stomach and gynaecological
pains, as well as to cure snake bites. (FAO)”
Garcinia lucida Vesque
While many plants have
antimicrobial properties, the effectiveness of Garcinia lucida appears to be due to naturally-present penicillin.
Penicillium is the name for a family of fungi found everywhere in our surroundings.
The Penicillium described in this study is an endophyte, which is typically a
bacterium or fungus that lives inside a plant without causing apparent disease.
In fact, many commercially important plants carry fungal endophytes which
enhance their growth, improve their ability to tolerate drought and even boost
their resistance to insects and mammals that eat them. Penicillin antibiotics
were among the first drugs shown to be tremendously effective against many
previously serious conditions, such as bacterial infections caused by
staphylococcus and streptococcus. Many types of commercially available
penicillins are still widely used today, although their overuse has made many
species of bacteria resistant to them. In the present study, the structures of
the three newly discovered penialidins were first determined using
sophisticated analytical methods such as nuclear magnetic resonance
spectroscopy (NMR) and high-resolution mass spectrometry (HRMS). Next, the
antibacterial activities of these new compounds were tested on the clinically
relevant species Staphylococcus aureus,
Escherichia coli, Bacillus subtilis and others. Penialidin
3 was seen to be as effective against S. aureus and B. subtilis as the standard
antibiotic streptomycin. Penialidin 2 was also very active against S. aureus. By comparing the structures
of the three new penialidins, the study researchers were able to deduce
structural changes that would significantly increase the antibacterial activity
of penialidin 1. In conclusion, three new penicillin-like compounds isolated
from the fungus Penicillium growing within the leaves of a medicinal plant from
Cameroon show clinically relevant antibacterial potential. Technical Summary Three new polyketides named
penialidins 1-3 were isolated from Penicillium harbored in the leaves of the
Cameroonian medicinal plant Garcinia
lucida. Their antibacterial efficacies were tested against S. aureus and E. coli. Penialidin 3
exhibited pronounced activity against S. aureus as well as against B. subtilis
similar to that of the standard antibiotic streptomycin. Penialidin 2 was also
highly active against S. aureus. Comparison of the structures of the three
compounds revealed that altering the substitutions at C-10 and C-2 can
significantly increase the antibacterial activity of Penialidin 1. See the full
article [LINK] for all the details. The
authors note:
“Compound 3 exhibited pronounced
activity against the clinically-relevant S.
aureus as well as against B. subtilis comparable to that of the reference standard
(streptomycin). Compound 2 was also highly-active against S. aureus. By
comparing the structures of the three new compounds (1-3), it was revealed that
altering the substitutions at C-10 and C-2 can significantly increase the
antibacterial activity of 1.”
epharmacognosy.com
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