Kitajima J, Kimizuka K, Tanaka Y. (2000), Three new sesquiterpenoid glucosides
of Ficus pumila fruit, Chem. Pharm. Bull. 48(1) 77—80
Abstract:
As
the glycosyl constituents of Ficus pumila L. fruits (Moraceae),
three new sesquiterpenoid glucosides, pumilasides A, B and C were isolated
together with benzyl beta-D-glucopyranoside, (E)-2-methyl-2-butenyl
beta-D-glucopyranoside and rutin. Their structures were characterized as
(1S,4S,5R,6R,7S,10S)-1,4,6-trihydroxyeudesmane 6-O-beta-D-glucopyranoside,
(1S,4S,5S,6R,7R,10S)-1,4-dihydroxymaaliane 1-O-beta-D-glucopyranoside and 10
alpha, 11-dihydroxycadin-4-ene 11-O-beta-D-glucopyranoside by spectral and
chemical methods.
INTRODUCTION:
The fruit of Ficus
(F.) pumila L. (Moraceae, o¯hitabi in Japanese) has been used
in Chinese folk medicine as antitumor, antiinflammatory and tonic medicament.1)
In previous papers,2) we reported on the sterol and triterpenoid
components of
this fruit. In this paper, we describe the isolation and characterization of
three new sesquiterpenoid glucosides from the fruit, together with
identification of the known glycosides. The methanolic extract of the fresh
fruit was suspended in water and then extracted with ether, ethyl acetate and n-butanol,
successively. The n-butanol extract was treated as described in
Experimental to isolate three new sesquiterpenoid glucosides, pumilaside A (1),
pumilaside B (2) and pumilaside C (3), together with the known
glycosides 4—6, which were identified as benzyl b -D-glucopyranoside,3)
(E)-2-methyl-2-butenyl b -D-glucopyranoside4) and rutin5) by comparison of
1H- and 13C-NMR spectra with those of authentic samples.
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