Cuscohygrine-Synonyms Cuskhygrine; Bellaradine

B. Cuscohygrine

Synonyms Cuskhygrine; Bellaradine.

Biological Sources It is obtained from the roots of Atropa belladona L. (Solanaceae) (Belladona, Deadly Nightshade); roots of Datura innoxia Mill. (Solanaceae) (Thorn Apple) upto 5-30%; seeds of Datura metal L. (Solanaceae) (Unmatal, Metel, Hindu Datura); leaves of Hyocyamus niger L. (Solanaceae) (Henbane, Henblain, Jusquaime); herb of Mandragora officinarum L. (Solanaceae) (Mandrake, Loveapple); rhizome of Scopolia carniolica Jacq. (Solanaceae) (Scopolia); and the roots of Withania somniferum (L.) Dunal (Solanaceae) (Ashwagandha).

Chemical Structure

1, 3-Bis (1-methyl-2-pyrrolidinyl)-2-propanone; (C₁₃H₂₄N₂O).

Isolation It is isolated from the naturally occurring plant sources by standard method.*

Characteristic Features

1. It is a oily liquid having bp₂₃ 169-170°C; bp₁₄ 152°C; bp₂ 118-125°C; d₄²⁰ 0.9733; n_D²⁰ 1.4832.

2. It is found to be miscible with water; and freely soluble in ethanol, ether, and benzene.

Identification Tests

1. Cuscohygrine Hemiheptahydrate: Its needles have mp 40°C.

2. Cuscohygrine Hydrobromide (C₁₃H₂₄N₂O.2HBr): It forms prisms from ethanol having mp 234°C.
Source:Pharmacognosy And Pharmacobiotechnology By Ashutosh Kar