2.5.1 Coumarin Glycosides
These are reported to be
present in about 150 different species spreading over to nearly 30 different families,
of which a few important ones are, namely: Caprifoliaceae, Leguminosae,
Oleaceae, Rubiaeeae, Solaneceae, and Umbelliferae.
This basic nucleus of coumarin
is considered to be derived from o-hydroxy cinnamic acid (or o-coumarin acid)
by its dehydration to yield the fused lactone ring as shown below:
It has been observed that
invariably most naturally occurring coumarins essentially bear an oxygen
atom either as hydroxyl (OH) or alkoxyl (—OCH3 or —OC2H5)
at C-7 position.
A few important naturally
occurring coumarin glycosides along with their respective biological sources
have been summarised in Table 4.3.
2.5.1.1 Coumarin Coumarin is
abundantly found in a variety of natural products which are used profusely as a
flavouring agent in pharmaceutical preparations.
Synonyms Tonka bean
camphor; Cumarin; Coumarimic anhydride.
Biological Source It is found in the tonka
seed, also known as tonquin beans or tonco seed i.e., Dipteryx
odorata Wild, and Dipteryx oppositifolia L., belonging to family Leguminosae.
It is also
obtained from Woodruff (Asperula species) and
in sweet clover i.e.; Melilotus alba Dess., family : Leguminosae.
Geographical Source These plants are found in
Europe, India and in the African continent.
Description
Colour : Colourless
Odour : Pleasant and fragrant odour resembling
that of vanilla beans.
Taste : Burning Taste
Shape : Orthorhombic, rectangular plates.
Chemical Structures Coumarin has the following
structure:
Uses It
is mostly employed as a pharmaceutical aid.
Source: Pharmacognosy And Pharmacobiotechnology By Ashutosh Kar
Source: Pharmacognosy And Pharmacobiotechnology By Ashutosh Kar
0 Comment:
Post a Comment