Antiplatelet, anticoagulant and fibrinolytic effects of Litchi chinensis Sonn. extract.
Sung, Yoon-Young; Yang, Won-Kyung; Kim, Ho Kyoung;
Center of Herbal Resources Research, Korea Institute of Oriental Medicine, Yuseong-gu, Daejeon 305-811, Republic of Korea.
Litchi chinensis Sonn. (lychee), which belongs to the family of
Sapindaceae, is a subtropical evergreen tree that is cultivated
throughout Southeast Asia, particularly in China. Litchi chinensis has
been reported to have anti-inflammatory, antioxidant and antidiabetic
activities. However, the antiplatelet and anticoagulant effects of
Litchi chinensis have not been reported previously. In this study, we
investigated the effects of a 70% ethanol extract from Litchi chinensis
(LCE) on platelet aggregation, coagulation and fibrinolysis. LCE
dose-dependently inhibited collagen- and ADP-induced platelet
aggregation in rat platelet-rich plasma. LCE at 4 mg/ml had a maximal
inhibitory effect on platelet aggregation. In particular, the LCE 4
mg/ml-treated group showed almost complete inhibition in the
collagen-induced platelet aggregation assay. It also significantly
prolonged coagulation times, such as the activated partial
thromboplastin and prothrombin time, in rat platelet-poor plasma. We
also investigated the fibrinolytic effects of LCE using the fibrin plate
assay. LCE increased fibrinolytic activity in a dose-dependent manner.
These results demonstrated the antithrombotic effects of LCE and suggest
that Litchi chinensis may be a new natural source for the development
of antiplatelet, anticoagulant and thrombolytic therapeutics for
thrombotic and cardiovascular diseases.
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