Ling Ding†, Hans-Martin Dahse†, and Christian Hertweck*†‡
† Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstraße 11a, 07745 Jena, Germany
‡ Friedrich Schiller University, 07737 Jena, Germany
J. Nat. Prod., Article ASAP
DOI: 10.1021/np2008544
Publication Date (Web): March 22, 2012
Several unusual alkaloids, N-2-methylpropyl-2-methylbutenamide (1), 2-acetyl-1,2,3,4-tetrahydro-β-carboline (2), fusarine (3), fusamine (4), and 3-(1-aminoethylidene)-6-methyl-2H-pyran-2,4(3H)-dione (5), were isolated from the culture broth of Fusarium incarnatum (HKI0504), an endophytic fungus of the mangrove plant Aegiceras corniculatum. Compounds 2, 4, and 5 exhibit weak antiproliferative and cytotoxic activities against HUVEC, K-562, and HeLa human cell lines, respectively.
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